In the late 15th century, with plague ravaging the land, Benedetta Carlini joins the convent in Pescia, Tuscany, as a novice. Capable from an early age of performing miracles, Benedetta’s impact on life in the community is immediate and momentous.

Rome, at the beginning of the 1980s. Giulio, Paolo and Riccardo are young and have big dreams. Soon Gemma, with whom Paolo is hopelessly in love, joins the boys. The years pass, the world and Italy change. The paths of the four separate, cross and intertwine again and again. And one day they all face the question of what is really important in life.